| Pair Name | Epigallocatechin gallate, Fluorouracil | ||
| Phytochemical Name | Epigallocatechin gallate (PubChem CID: 65064 ) | ||
| Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Epigallocatechin gallate, Fluorouracil | |||
| Disease Info | [ICD-11: 2B91] | Colorectal cancer | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Down-regulation | Expression | ABCB1 | hsa5243 |
| Down-regulation | Expression | ABCB1 | hsa5243 | |
| Up-regulation | Expression | BAD | hsa572 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Down-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Expression | MIR155 | hsa406947 | |
| Up-regulation | Activity | NFKB1 | hsa4790 | |
| Up-regulation | Cleavage | PARP1 | hsa142 | |
| In Vitro Model | DLD-1 | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0248 |
| HCT 116 | Colon carcinoma | Homo sapiens (Human) | CVCL_0291 | |
| Result | Our data show that EGCG may be act as a novel chemo-sensitizer, and the GRP78/NF-κB/miR-155-5p/MDR1 pathway plays a vital role in EGCG enhancing the sensitivity of colorectal cancer to 5-FU. | |||
| No. | Title | Href |
|---|---|---|
| 1 | (-)-Epigallocatechin Gallate (EGCG) Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU by Inhibiting GRP78/NF-κB/miR-155-5p/MDR1 Pathway. J Agric Food Chem. 2019 Mar 6;67(9):2510-2518. doi: 10.1021/acs.jafc.8b06665. | Click |
